Ginkgo.Your Innovation Partner.
Recent advances in AI have enabled remarkable progress in the design and optimization of messenger RNA (mRNA) for RNA vaccines and therapeutics. While recent work on mRNA design has largely focused on designing individual components of the mRNA sequence, designing end-to-end mRNA sequences presents a unique challenge. Specifically, designing functional mRNA requires joint optimization of the coding sequence (CDS) for a protein of interest in addition to the 3’ and 5’ untranslated regions (UTRs).
Recently, diffusion models have emerged as a powerful generative framework for protein design and sequence generation, for example, Ginkgo's recently released antibody discrete diffusion model. Building on these advances, we introduce mRNA discrete diffusion (mDD-0), a discrete diffusion model for the generation of mRNA sequences.
